منابع مشابه
Rab3 GTPase Lands Bruchpilot
Active zones are the sites of neurotransmitter release, but their assembly mechanisms are poorly understood. In this issue of Neuron, Graf et al. perform a genetic screen in Drosophila and uncover a novel role for the Rab3 GTPase in organizing the active zone at the neuromuscular junction.
متن کاملRab3 Dynamically Controls Protein Composition at Active Zones
Synaptic transmission requires the localization of presynaptic release machinery to active zones. Mechanisms regulating the abundance of such synaptic proteins at individual release sites are likely determinants of site-specific synaptic efficacy. We now identify a role for the small GTPase Rab3 in regulating the distribution of presynaptic components to active zones. At Drosophila rab3 mutant ...
متن کاملMolecular cloning and characterization of the noncatalytic subunit of the Rab3 subfamily-specific GTPase-activating protein.
We recently purified and characterized from rat brain a GTPase-activating protein (GAP) specific for the Rab3 small G protein subfamily implicated in Ca2+-dependent exocytosis. Rab3 GAP showed two bands with Mr of about 130,000 (p130) and 150,000 (p150) on SDS-polyacrylamide gel electrophoresis. p130, but not p150, showed the catalytic activity. Because p150 was likely the subunit of Rab3 GAP, ...
متن کاملRab3-GEF Controls Active Zone Development at the Drosophila Neuromuscular Junction.
Synaptic signaling involves the release of neurotransmitter from presynaptic active zones (AZs). Proteins that regulate vesicle exocytosis cluster at AZs, composing the cytomatrix at the active zone (CAZ). At the Drosophila neuromuscular junction (NMJ), the small GTPase Rab3 controls the distribution of CAZ proteins across release sites, thereby regulating the efficacy of individual AZs. Here w...
متن کاملMADD is highly homologous to a Rab3 guanine-nucleotide exchange protein (Rab3-GEP)
Our brains continuously bind information obtained through many sensory channels to form solid percepts of objects and events. Usually these pieces of information complement and confirm each other, thereby improving the reliability of our perception [1]. But incongruities between the sensory inputs may result in unexpected percepts due to intersensory interactions, as in the well-known audiovisu...
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ژورنال
عنوان ژورنال: Neuron
سال: 2009
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2009.11.029